DESMOID TUMORS: PATHOPHYSIOLOGY,EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT MODALITIES
Main Article Content
Desmoid tumors are benign tumors that can be locally agressive. These tumors are infrequent. The incidence is 2.4 to 4.3 % cases per million in general population. Little is known about the true pathophysiology of these tumors. Hormonal, genetic, trauma have been reported for occurence of desmoid tumors. But most commonly desmoid tumors are idiopathic. They may be associated with Gardner syndrome and mutations of the familial adenomatous polyposis (FAP) gene. Spontaneous desmoid tumors most commonly are related with beta-catenin gene mutations. This beta-catenin defect causes activation of Wnt/catenin signaling. Desmoid tumors of head and neck region consist of 7-15% of all desmoid cases. The localizations of the tumor is variable. The behaviour and clinical course can not be estimated.For these characteristics there is no standard consensus on treatment approach. Treatment of desmoid tumors based on surgical. The aim of surgery is to maintain low recurrence and morbidity.We wanted to remind the etiology,pathophysiology and treatment modalities under guidance of the literature.
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.