This issue addresses the rapid advancements in radiology, focusing on the integration of artificial intelligence and machine learning to enhance imaging processes. It discusses the development of novel contrast agents and the importance of optimizing radiation doses and image quality. The issue also emphasizes the need for harmonizing imaging data and the continuous education of professionals in this digitally transforming field. Featuring original research, reviews, and case reports, it aims to inform and guide radiologists, researchers, and students about the latest developments and debates within medical imaging.