B-type natriuretic peptide and renovascular hypertension; is there any relation?

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Shokoufeh Hajsadeghi Yaghoub Bagheri Mohammad Javad Manteghi Ata Firouzi Scott Reza Jafarian Kerman Morteza Hassanzadeh

Abstract

Renal artery stenosis (RAS) is the most prevalent cause of secondary hypertension (HTN). Percutaneous trans-luminal renal angioplasty (PTRA) is used for both diagnosis and treatment of RAS. As many as one third of RAS cases fail to demonstrate post-PTRA HTN improvement. In this study, brain natriuretic peptide (BNP) was measured for consecutive patients with refractory HTN referred for renal artery angiography and 2 groups of participants (essential HTN and RAS) were compared. BNP was found significantly higher among RAS group than those with essential HTN (P <0.001) and had a good sensitivity (76%) to discriminate RAS from essential HTN. RAS cases also showed a statistically significant decline in BNP level (P <0.001) after PTRA. We concluded that BNP is increased in RAS before intervention, is declined after PTRA, and might be used both as a marker for discriminating RAS from essential refractory HTN and for post-PTRA follow-up.

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How to Cite
HAJSADEGHI, Shokoufeh et al. B-type natriuretic peptide and renovascular hypertension; is there any relation?. Medical Research Archives, [S.l.], v. 5, n. 6, june 2017. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/1376>. Date accessed: 30 jan. 2023.
Keywords
BNP, Hypertension, Renal artery stenosis, Angioplasty
Section
Research Articles