Abstract
Natural rubber latex is derived from the lactiferous sap of the Hevea brasiliensis (para rubber tree) and has been used in traditional medicine due to its bioactive compounds. There are over 35,000 species of plants that produce latex. Recently, NRL has shown promise in tissue engineering for the replacement and regeneration of various tissues, such as skin, eardrums, bones, and dental alveoli. This presents a unique opportunity to repair or replace failing organs or tissues. This review highlights the current development of Natural rubber latex in tissue engineering, and identifies importance for investigation on cytotoxicity of Natural rubber latex nanoparticles. In addition, promising results regarding the current challenges and perspectives of Natural rubber latex-based tissue engineering is discussed.