Is bilateral multiple lung tumor resection an acceptable therapeutic option for pulmonary epithelioid hemangioendothelioma?

Main Article Content

Keisuke Eguchi Junichi Matsui


Pulmonary epithelioid hemangioendothelioma is a rare pulmonary neoplasm. No reliably effective systemic chemotherapy for this disease entity has been established yet. Surgery is usually applied for patients with a small number of lesions limited to one lung, while feasibility/efficacy/safety of this modality is controversial for patients with bilateral multiple lung lesions.  Presence of cases showing rapid aggravation and those showing very gradual progression makes it difficult to evaluate validity of surgery as a suitable therapeutic approach. Herein, we present a summary on pulmonary epithelioid hemangioendothelioma and discuss the role of surgery in the treatment of this condition.

Article Details

How to Cite
EGUCHI, Keisuke; MATSUI, Junichi. Is bilateral multiple lung tumor resection an acceptable therapeutic option for pulmonary epithelioid hemangioendothelioma?. Medical Research Archives, [S.l.], v. 5, n. 2, feb. 2017. ISSN 2375-1924. Available at: <>. Date accessed: 23 sep. 2021.
Medical Research Archives
Review Articles


1) Amin RM, Hiroshima K, Kokubo T, et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid
haemangioendothelioma. Review of the literature and a case report. Respirology 2006;11(6):818-825.
2) Bagan P, Hassan M, Le Pimpec Barthes F, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg. 2006;82(6):2010-2013.
3) Corrin B, Manners B, Millard M, et al. Histogenesis of the so-called "intravascular bronchioloalveolar tumour". J Pathol. 1979;128(3):163-167.
4) Dail DH, Liebow AA. lntravascular bronchioloalveolar tumor. Am J Pathol 1975;78:6a-7a.
5) Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer. 1983;51(3):452-464.
6) Eguchi K, Sawafuji M. Surgical management of a patient with bilateral multiple pulmonary epithelioid hemangioendothelioma: report of a case. Surg Today. 2015;45(7):904-906.
7) Ergun EL, Lim E. Increased FDG uptake in pulmonary epitheloid
hemangioendothelioma. Rev Esp Med Nucl 2006;25:188–192.
8) Fagen K, Silverman ED, Cole Rl. Detection of a pulmonary epithelioid hemangioendothelioma by FDG PET scan. ClinNucl Med 2004;29:758–759.
9) Kim M, Chang J, Choi H, et al. Pulmonary epithelioid hemangioendothelioma misdiagnosed as a benign nodule. World J Surg Oncol. 2015;13:107.
10) Kitaichi M, Nagai S, Nishimura K, Itoh H, Asamoto H, Izumi T,et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J 1998;12(1):89–96.
11) Lau K, Massad M, Pollak C, et al. Clinical Patterns and Outcome in Epithelioid Hemangioendothelioma With or Without Pulmonary Involvement: Insights From an Internet Registry in the Study of a Rare Cancer Chest 2011; 140(5): 1312-1318
12) Marsh K, Kenyon WE, Earis JE, et al. Intravascular bronchioloalveolar tumour. Thorax. 1982;37(6): 474–475.
13) Minah Kim, Jinsun Chang, Hayoung Choi, Pulmonary epithelioid hemangioendothelioma misdiagnosed as a benign nodule
World Journal of Surgical Oncology2015;13:107
13) Pinet C, Magnan A, Garbe L, et al. Aggressive form of pleural epithelioid haemangioendothelioma: complete response after chemotherapy. Eur Respir J. 1999;14(1):237-238.
14) Rest CC, Botton E, Robinet G, et al. FDG PET in epithelioid
hemangioendothelioma.Clin Nucl Med 2004;29:789–792.
15) Rock MJ, Kaufman RA, Lobe TE, Hensley SD, Moss ML. Epithelioid hemangioendothelioma of the lung (intravascularbronchioloalveolar tumor) in a young girl. Pediatr Pulmonol 1991;11(2):181–186.
16) Roudier-Pujol C, Enjolras O, Lacronique J, et al. Multifocal epithelioid hemangioendothelioma with partial remission after interferon alfa-2a treatment. Ann Dermatol Venereol. 1994;121(12):898-904.
17) Schattenberg T, Kam R, Klopp M, et al. Pulmonary epithelioid hemangioendothelioma: report of three cases. Surg Today 2008;38(9):844-849.
18) Takahashi K, Nishimura M. A unique collision of epithelioid hemangioendothelioma and bronchioloalveolar carcinoma in a 54-year-old Japanese woman. Jpn J Thorac Cardiovasc Surg. 2003;51(7):311-3.
19) Teo SK, Chiang SC, Tan KK. Intravascular bronchioloalveolar tumour. A 20-year survival. Med J Aust. 1985;142(3):220-222.

20) Watanabe S, Yano F, Kita T et al. 18F-FDG-PET/CT as an indicator for resection of pulmonary epithelioid hemangioendothelioma. Ann Nucl Med 2008; 22:521–524
21) Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50(5):970-81.
22) Weldon-Linne CM, Victor TA, Christ ML, et al. Angiogenic nature of the "intravascular bronchioloalveolar tumor" of the lung: an electron microscopic study. Arch Pathol Lab Med. 1981;105(4):174-179.
23) Woodall CE, Scoggins CR, Lewis AM, et al Hepatic malignant
epithelioid hemangioendothelioma: a case report and review of the literature
Am Surg 2008;74 (1) :pp. 64–68