Non-Aneurysmal Subarachnoid Hemorrhage in COVID-19: A Case Report and Review of Literature

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Ritwik Ghosh, MD Dipayan Roy, MD Adrija Ray, MBBS Shambaditya Das, MD, DM Amrita Mandal, MBBS Shambaditya Das, MD, DM Shyamal Kanti Pal, MD Julián Benito-León, MD, PhD


Background: Hemorrhagic cerebrovascular events, either due to aneurysmal rupture or spontaneous subarachnoid hemorrhage (SAH), are not rare in COVID-19. Several mechanisms such as coagulopathy, cytokine storm, viral endotheliopathy, hypertension, and immune modulation might play a role in the pathogenesis of SAH in COVID-19. This study aimed to report the first case of spontaneous non-aneurysmal SAH associated with SARS-CoV-2 from India. We briefly discussed the possible pathogenetic mechanisms underlying this process and succinctly reviewed the relevant literature.

Case report: We herein report a case of a non-comorbid young woman infected with SARS-CoV-2 presenting with thunderclap headache and eventually non-aneurysmal SAH,  who recovered with conservative management.

Conclusion: Headache, although a very common clinical feature of COVID-19 itself, must be investigated in detail to identify alternate causes that may be life-threatening. This case also incites further enquiry into the possible pathogenic mechanisms of neurovascular complications in COVID-19.

Keywords: Neuro-COVID, subarachnoid hemorrhage, COVID-19, endotheliitis, coagulopathy

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How to Cite
GHOSH, Ritwik et al. Non-Aneurysmal Subarachnoid Hemorrhage in COVID-19: A Case Report and Review of Literature. Medical Research Archives, [S.l.], v. 10, n. 1, jan. 2022. ISSN 2375-1924. Available at: <>. Date accessed: 17 apr. 2024. doi:
Case Reports


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