Variability in the Prevalence of Microsatellite Instability in Colon Cancer

Main Article Content

Brad David Barrows Neda Zarrin-Khameh http://orcid.org/0000-0001-7506-156X

Abstract

BACKGROUND – Microsatellite instability is an important contributor to sporadic and familial colon cancer. Dysfunction of DNA mismatch-repair proteins by mutation or promoter methylation is a well-recognized cause of microsatellite instability. We conducted a study to identify variations in the prevalence of mismatch-repair protein deficiency in colon cancer and analyze clinical characteristics that may contribute to differences among ethnic subgroups of a community hospital-based patient population.

METHOD – A retrospective analysis of 272 cases was performed.

RESULTS – Reduced prevalence of mismatch-repair protein dysfunction was found in all non-Latino ethnicities (3.6%) compared to the Latino (13.1%) portion of our patient population (p=0.007). Mismatch repair protein deficient colon cancer was found to show significant correlation with right side location (p=0.017), young age in non-Latino ethnicities (p=0.030), tumor stage IIIC or greater (p=0.006), and high-grade histology (p=0.003). Colon cancer patients of Latino descent appear to have an increased rate of germline mutations within mismatch repair genes.

CONCLUSION – The prevalence of mismatch repair protein dysfunction in the non-Latino ethnicities of our patient population are less than reported in literature, while the rate of germline mutations within mismatch repair genes appears increased in those of Latino descent.

Article Details

How to Cite
BARROWS, Brad David; ZARRIN-KHAMEH, Neda. Variability in the Prevalence of Microsatellite Instability in Colon Cancer. Medical Research Archives, [S.l.], v. 5, n. 4, apr. 2017. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/1118>. Date accessed: 16 apr. 2024.
Keywords
Colon cancer, MSI, Immunohistochemical Stain
Section
Research Articles

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